Pharma Research Bulletin – Pharmaceutical & Clinical Research Updates

Volume 2, 2020

Number of Articles - 05
Research Article

Antibacterial Activity of Cynodon dactylon leaf Extract

M. Syam Vardhan*, K.Narayana, B. Saradhi, B. Swaroop, P. Venkateswara Rao.

Department of Pharmacognosy, St. Mary’s Group of Institutions, Guntur-522212, Andhra Pradesh, India.

Abstract

Antibacterial Activity of Cynodon dactylon leaf Extract

Cynodon dactylon (Leaf) is a type of grass that possesses great medicinal values. Moreover, medicinal plants are the important source of potentially useful structures for the development of novel antimicrobial agents. Historically, plants have provided a source of the development for novel drugs and plant derived drugs which have made large contributions to human health and well-being. Till now very few plants have been scientifically proved by different researchers for their medicinal potential but the therapeutic ability of number of plants are still unknown. In this study, take four different solvents (chloroform, acetone, ethanol and water) in the order to enhance the polarity nature and finally with distilled water. These were used to investigate the phytochemical constituents of the plant to extract the bioactive compounds from the leaf of Cynodon dactylon to screen the antimicrobial activity. Antimicrobial study of methanol and aqueous extracts showed antimicrobial activity against the tested pathogens. Antimicrobial activity was reported due to presence of bioactive compounds.
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Vardhan MS, Narayana K, Saradhi B, et. al. Antibacterial Activity of Cynodon dactylon leaf Extract. PRB, 2019;1(1):1-6.

Research Article

In-vivo Evaluation of Antidepressant Activity in Ziziphus jujuba on Albino Rats by Tail Suspension Test (TST) & Force Swim Test (FST) Methods

K. Naga Rani*, P. Venkateswara Rao, K. Sirisha, P. Vijaya Lakshmi, Mahimudh Arief.

Department of Pharmacology, St. Mary’s Group of Institutions, Guntur-522212, Andhra Pradesh, India.

Abstract

In-vivo Evaluation of Antidepressant Activity in Ziziphus jujuba on Albino Rats by Tail Suspension Test (TST) & Force Swim Test (FST) Methods

The objective of the present study was to evaluate the anti-depressant activity of Zizipus jujube. Ziziphus jujuba (Rhamnaceae) is a traditional medicinal plant known as jujube. This plant has been used for the treatment of a variety of diseases. This study was done to evaluate the possible antidepressant effect of Ziziphus jujuba pulp extract (ZJPE) using tail suspension test (TST) & forced swim test (FST). Group-I (control) received normal saline (1ml/100gm), GroupII, III & IV received ZJPE in doses of 20, 30, 40 mg/kg orally (P.O.) respectively. Group V (positive control) received Imipramine at doses of 15mg/kg p.o. respectively. Drug treatment was given for seven & fourteen successive days and after 60 minutes interval last dose of drug or standard the immobility period was recorded. ZJPE produced significant antidepressant like effect at dose of 20, 30& 40 mg/kg administered for 7 & 14 consecutive days as indicated by reduction in immobility times of rat in TST & FST (P<0.05). The efficacy of ZJPE at 30mg/kg was found to be comparable to that of Imipramine at doses of 15mg/kg.
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Rani KN, Rao PV, Sirisha K, et al. In-vivo Evaluation of Antidepressant Activity in Ziziphus jujuba on Albino Rats by Tail Suspension Test (TST) & Force Swim Test (FST) Methods. PRB, 2019;1(1):7-12.

Research Article

Standardization of Several Commercial Polyherbal Formulations containing Withania somnifera Linn.

Suresh Kumar*, Rameshwar Dass.

G. D. Goenka University, Sohna, Gurugram, Haryana, India.

Abstract

Standardization of Several Commercial Polyherbal Formulations containing Withania somnifera Linn.

India has a rich heritage of traditional medicines which has been flourishing since from very long time. With the ever-increasing use of herbal medicines worldwide and the rapid expansion of the global market for these products, the safety and quality of medicinal plant materials and finished herbal medicinal products have become a major concern for health authorities, pharmaceutical industries and the public. In the present study several pharmaceutical standardization parameters of three commercial available Ayurvedic polyherbal formulations i.e. Ashwaganda churna (Aswajith), Ashwaganda lehya (Ashwagandhadi Lehyam) and Ashwaganda arista (Ashwagandharistam) are discussed. In addition, the estimation of active constituents of Ashwagandha particularly withanolide-A and withaferin-A in all three formulations was carried out using HPTLC.
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Kumar S, Dass R. Standardization of Several Commercial Polyherbal Formulations Containing Withania somnifera Linn. PRB, 2019;1(1):13-22.

Review Article

Total Quality Management (TQM) and Knowledge Management – A Review.

K. Sudheer*, Chilka Vinod Kumar, Brahmaiah Bonthagarala, M. V. Nagabhushanam, D.
Nagarjuna Reddy, G. Ramakrishna.

Department of Pharmaceutical Management and Regulatory Affairs, Hindu College of Pharmacy, Amaravathi Road, Guntur–522002, Andhra Pradesh, India.

Abstract

Total Quality Management (TQM) and Knowledge Management - A Review

This research study seeks to come up with a conceptual framework that investigates the different dimensions of total quality management (TQM) and its effects on knowledge management (KM). This is to help build a theoretical framework of TQM and its dimensions, which mainly consists of leadership, strategic planning, information and analysis, process management, human resource focus and customer focus. These constructs are rooted in the work of Malcolm Baldrige National Quality Award (MBNQA). The current research study is based on the complete assessment of present literatures, the six constructs of TQM and the three elements of knowledge acquisition, knowledge application and knowledge dissemination. This paper serves as a guide to senior management, who seeks to improve their company’s organizational knowledge management activities through the execution of TQM practices, in which the TQM practices support their company’s knowledge management efforts. Furthermore, the conceptual model serves as a benchmark for practitioners to execute their TQM programmes more effectively and efficiently in their own respective firms. By developing a deeper understanding of the relationship between TQM practices and knowledge management, senior management can thus focus their efforts on the practices that ensure the firms’ ability to establish a competitive knowledge management capability.
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Sudheer K, Kumar CV, Bonthagarala B, et al. Total Quality Management (TQM) and Knowledge Management - A Review. PRB, 2019;1(1):23-32.

Review Article

Validation and Verification of Medical Devices.

Chilka Vinod Kumar*, K. Sudheer, Brahmaiah Bonthagarala, M. V. Nagabhushanam, D.
Nagarjuna Reddy, G.Ramakrishna.

Department of Pharmaceutical Management and Regulatory Affairs, Hindu College of Pharmacy, Amaravathi Road, Guntur–522002, Andhra Pradesh, India.

Abstract

Validation and Verification of Medical Devices

Every marketable medical device needs deep level engagement, considering the complexities involved due to the requirements, usage patterns, user experience, regulations, associated iterative process, technologies, material, and many more. To stay in line with competition or decrease time-to-market, you may need help from an experienced medical device engineering consultants or service providers. Medical devices are also becoming smaller and more complex in design, sometimes using advanced, engineered plastics. This makes the process of validation and verification (V&V) even more important not only to comply with regulations, but also design the highest quality part and production process. The result is better repeatability, fewer mistakes, less rework and redesign, faster time to market, improved competitiveness, and lower production costs. U.S. Food and Drug Administration (FDA) and international regulatory standards continue to evolve and become more stringent rules in Medical Devices. Validation & Verification (V&V) are required as part of designing and developing a medical device, as part of implementing a manufacturing production process or an automated system, as part of ensuring the appropriateness of a design, production or other process change, and as part of ensuring that a corrective or preventive action is effective and does not adversely impact product.
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Chilka VK, Sudheer K, Bonthagarala B, et al. Validation and Verification of Medical Devices. PRB, 2019;1(1):33-41.