Zinc is vital for human health, playing key roles in essential physiological processes like DNA synthesis, immune function, and cellular activity. Despite its significance, zinc deficiency is a widespread health issue impacting billions worldwide. While zinc supplementation is commonly used, incorporating plant- based foods rich in phytochemicals presents an additional strategy to combat zinc insufficiency. Phytochemicals, abundant in fruits, vegetables, and legumes, interact with zinc in intricate ways, influencing how it is absorbed and utilized by the body. However, the relationship between plant compounds and zinc absorption is complex, with some compounds facilitating absorption while others impede it. Understanding these interactions is critical for optimizing dietary approaches to prevent zinc deficiency. Dietary factors, especially in regions where cereal-based diets dominate and lack diverse plant foods rich in zinc, exacerbate the prevalence of zinc insufficiency. Zinc deficiency can go unnoticed, posing challenges for diagnosis due to its varied physiological effects. Plant-derived compounds like polyphenols, flavonoids, and saponins have emerged as potential allies in addressing zinc deficiency, yet their effects vary depending on the context. While zinc supplementation remains a common method, recent research suggests that plant-based compounds hold promise in enhancing zinc absorption. This review delves into the history of zinc research, its physiological impacts, absorption mechanisms, and therapeutic potentials. Furthermore, it explores the role of plants in human zinc therapy, offering insights into future approaches to tackling zinc deficiency through plant-based interventions. Collaborative efforts spanning various disciplines are essential to effectively address the global burden of zinc deficiency and advance public health outcomes.